Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program. Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions. Includes summary boxes that assist with rapid review and mastery of key material. This enhanced eBook experience allows you to search all of the text, figures, references and animations, designed to produce a more rounded learning experience.
Features updates from cover to cover , including tumor immunity tumor antigens, cancer immunotherapy , immune checkpoints, cytosolic sensors for DNA, non-canonical inflammasomes, prionization as a signaling mechanism, monogenic defects in immunity, and more.
Download PDF. Kennedy Blvd. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notice Knowledge and best practice in this field are constantly changing. As new research and experience broaden our knowledge, changes in practice, treatment and drug therapy may become necessary or appropriate.
Readers are advised to check the most current information provided i on procedures featured or ii by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on their own experience and knowledge of the patient, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
Include index. ISBN 1. Helbert, Matthew. N In preparing this edition, we have made improvements We are aware of two specific problems that medical throughout to improve the clarity and accessibility of the students have with immunology. First,the immune system is material. We have updated all the sections, particularly the complex, because it has evolved to respond to the wide material dealing with Toll-like receptors, dendritic cells, range of pathogens. Many students find themselves bogged regulatory T cells, and HIV.
We have also introduced a final down in the complexities of the molecules and cells of the chapter on therapeutic immunomodulation,which is being immune system, without having an understanding of how increasingly utilized in clinical practice. This chapter also these components work together to fight infection. We aims to review what readers will have learned about the begin our book with two overview chapters that explain immunopathogenesis of several diseases covered in earlier what the immune system does and then how the compo- chapters.
In response to user feedback, we have also en- nents fit together. We recommend that students begin by hanced the clinical vignettes, which form the final pages of reading these chapters. Further on in the text, there are most chapters. Although some of these vignettes describe more short, integrating overview chapters. These are not rare diseases, we hope that this helps readers link their just for revision, but are there to make sure that the student studies of immunology with real clinical experience.
We have in- cluded clinical correlations throughout the text, which We have recognized the need for an immunology book that explain how understanding the science of immunology is primarily focused on the needs of medical students for as can translate into understanding real clinical problems. This book The book is a concise description of the science of im- has been written to fill this need. Immunology can fall into munology, a topic that defies a final complete description, different medical school courses or modules.
Often, the because there is much still to be learned. Hopefully, we immunology is taught in the Host Defense course, which will have succeeded in inducing an interest and apprecia- integrates basic and clinical immunology including allergy, tion of the relevance of immunology to medical students, immunopathology, etc. Some medical schools, however, to form the basis for a lifetime of learning about the teach basic immunology and clinical immunology in two immune system and its potential for use in improving the separate courses.
This book should be useful for either human condition. Most medical students today could still curriculum organization. Approximately We have concentrated on a simple, straightforward treat- 50 years ago, immunology was still in its infancy. For exam- ment of the subject. The book is relatively short and con- ple, we did not know the chemical structure of antibody tains the topics we considered important to understand molecules in any detail, and treatments such as organ trans- the human immune system and its role in protecting us plantation had not been carried out.
The next 50 years from disease. This reflects our acknowledgment of the will likely bring equally important advances in the field. With new History suggests that we would be foolish to try to predict topics and a growing amount of information considered to what they will be. We hope that you enjoy participating in be essential, there are increasing demands on students.
It is these advances in immunology and their application to therefore important to have a concise, readable textbook, human disease as much as we have in those that we have and that has been our primary aim.
Most chapters contain been privileged to observe in our careers. This, of course, R. This edition is changing subject and provided me with invaluable mate- dedicated to my family and to all the medical students I rial for publication.
I would not have been able to write have had the opportunity to teach and learn from. You comprehensively. The flow of the book is from genes and should become familiar with them immediately to follow molecules to cells and organs, and finally to the immune the illustrations.
We have selected several pathogens listed system as an integrated system protecting the body from in the figure overleaf to use throughout the book as exam- infection and helping to maintain the health of the body. As a reminder, some basic aspects of the structure and Section 1 introduces the basic concepts and is essential mechanism of action of these organisms are described.
You for an understanding of the language of immunology. In general, boxes have been clustered at the end of Section 3 deals with immune physiology, the role of the chapters in the second edition to aid in the flow of the cells and organs of the immune system in the response to text and in understanding of the material.
Section 4 discusses the innate immune system and its connections to the adaptive immune system. The clinical material selected is nomodulation. Throughout the book, the core knowledge objectives are listed as Learning Points at the ends of chapters to aid in review. There are also several integrating overview chapters e. Each section is relatively freestanding.
Immunology for Medical Technical boxes show how advances in the field have Students will be most useful in the comprehensive Host expanded our knowledge of how the immune system works, and provided new means of preventing disease. Defense-type courses that are growing in popularity in medical schools. The mechanisms used by the immune system in response to each of these infections is described in detail in different chapters of this book.
HIV has a small genome that frequently mutates, allowing escape from the immune response. Most infected individuals do not develop adequate immunity to clear the virus. Infection frequently results in AIDS.
No vaccine exists. Influenza virus RNA virus Influenza causes global epidemics.
0コメント